Compound Detail
CHEMBL206524
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Basic Information
| ChEMBL ID | CHEMBL206524 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KKVZKYOBQGDKIB-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
429.5
MW (Da)
4.65
ALogP
8
HBA
1
HBD
94.2
PSA (Ų)
0.44
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 8.05 | 8.05 | 9.0 | 1 |
| Focal adhesion kinase 1 CHEMBL2695 | IC50 | 7.03 | 7.03 | 93.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 9.0 | nM | 8.05 | Inhibition of casein kinase-2 in human PASMC incubated for 24 hrs assessed as re... | - |
| Focal adhesion kinase 1 | IC50 | = | 93.0 | nM | 7.03 | Inhibition of FAK | 16524731 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16524731 | 10.1016/j.bmcl.2006.02.032 | Focal adhesion kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine