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Assay Detail

CHEMBL870124

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of FAK
ChEMBL ↗
77
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Focal adhesion kinase 1 (CHEMBL2695) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of 7H-pyrrolo[2,3-d]pyrimidines as focal adhesion kinase inhibitors. Part 2.
Choi HS, Wang Z, Richmond W, He X, Yang K, Jiang T, Karanewsky D, Gu XJ, Zhou V, Liu Y, Che J, Lee CC, Caldwell J, Kanazawa T, Umemura I, Matsuura N, Ohmori O, Honda T, Gray N, He Y.
Bioorg Med Chem Lett (2006) 16 : 2689 -2692
PubMed 16524731 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 77 6.34 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL207491 — — 1 8.40
CHEMBL207084 — — 1 7.54
CHEMBL207605 — — 1 7.46
CHEMBL206255 — — 1 7.43
CHEMBL379837 — — 1 7.42
CHEMBL207131 — — 1 7.42
CHEMBL207961 — — 1 7.27
CHEMBL382354 — — 1 7.20
CHEMBL207499 — — 1 7.20
CHEMBL377708 — — 1 7.14
CHEMBL206524 — — 1 7.03
CHEMBL208419 — — 1 6.94
CHEMBL439154 — — 1 6.93
CHEMBL209044 — — 1 6.92
CHEMBL207015 — — 1 6.90
CHEMBL208370 — — 1 6.74
CHEMBL205098 — — 1 6.67
CHEMBL207614 — — 1 6.66
CHEMBL204686 — — 1 6.63
CHEMBL207737 — — 1 6.63
CHEMBL206876 — — 1 6.63
CHEMBL380312 — — 1 6.62
CHEMBL380515 — — 1 6.58
CHEMBL380226 — — 1 6.56
CHEMBL207444 — — 1 6.53
CHEMBL380683 — — 1 6.50
CHEMBL208468 — — 1 6.49
CHEMBL207126 — — 1 6.48
CHEMBL208939 — — 1 6.47
CHEMBL382192 — — 1 6.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL207491 — IC50 = 4.0 nM 8.40
CHEMBL207084 — IC50 = 29.0 nM 7.54
CHEMBL207605 — IC50 = 35.0 nM 7.46
CHEMBL206255 — IC50 = 37.0 nM 7.43
CHEMBL379837 — IC50 = 38.0 nM 7.42
CHEMBL207131 — IC50 = 38.0 nM 7.42
CHEMBL207961 — IC50 = 54.0 nM 7.27
CHEMBL382354 — IC50 = 63.0 nM 7.20
CHEMBL207499 — IC50 = 63.0 nM 7.20
CHEMBL377708 — IC50 = 73.0 nM 7.14
CHEMBL206524 — IC50 = 93.0 nM 7.03
CHEMBL208419 — IC50 = 115.0 nM 6.94
CHEMBL439154 — IC50 = 117.0 nM 6.93
CHEMBL209044 — IC50 = 119.0 nM 6.92
CHEMBL207015 — IC50 = 126.0 nM 6.90
CHEMBL208370 — IC50 = 182.0 nM 6.74
CHEMBL205098 — IC50 = 212.0 nM 6.67
CHEMBL207614 — IC50 = 221.0 nM 6.66
CHEMBL204686 — IC50 = 236.0 nM 6.63
CHEMBL207737 — IC50 = 235.0 nM 6.63
CHEMBL206876 — IC50 = 232.0 nM 6.63
CHEMBL380312 — IC50 = 242.0 nM 6.62
CHEMBL380515 — IC50 = 262.0 nM 6.58
CHEMBL380226 — IC50 = 278.0 nM 6.56
CHEMBL207444 — IC50 = 298.0 nM 6.53
CHEMBL380683 — IC50 = 314.0 nM 6.50
CHEMBL208468 — IC50 = 322.0 nM 6.49
CHEMBL207126 — IC50 = 331.0 nM 6.48
CHEMBL208939 — IC50 = 342.0 nM 6.47
CHEMBL382192 — IC50 = 339.0 nM 6.47
CHEMBL207259 — IC50 = 345.0 nM 6.46
CHEMBL378661 — IC50 = 365.0 nM 6.44
CHEMBL208384 — IC50 = 397.0 nM 6.40
CHEMBL207721 — IC50 = 421.0 nM 6.38
CHEMBL379279 — IC50 = 434.0 nM 6.36
CHEMBL206731 — IC50 = 504.0 nM 6.30
CHEMBL208368 — IC50 = 507.0 nM 6.29
CHEMBL206927 — IC50 = 544.0 nM 6.26
CHEMBL207232 — IC50 = 635.0 nM 6.20
CHEMBL425418 — IC50 = 634.0 nM 6.20
CHEMBL207834 — IC50 = 727.0 nM 6.14
CHEMBL208734 — IC50 = 727.0 nM 6.14
CHEMBL379655 — IC50 = 831.0 nM 6.08
CHEMBL380424 — IC50 = 882.0 nM 6.05
CHEMBL208000 — IC50 = 983.0 nM 6.01
CHEMBL379969 — IC50 = 1330.0 nM 5.88
CHEMBL207053 — IC50 = 1510.0 nM 5.82
CHEMBL381374 — IC50 = 1507.0 nM 5.82
CHEMBL381262 — IC50 = 1530.0 nM 5.82
CHEMBL383263 — IC50 = 1810.0 nM 5.74