Assay Detail
Binding
CHEMBL4337198
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Inhibition of human histamine H3 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.00 | 7.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4173258 | — | — | 1 | 7.97 |
| CHEMBL14638 | CIPROXIFAN | — | 1 | 7.34 |
| CHEMBL3323035 | — | — | 1 | 7.12 |
| CHEMBL1929421 | — | — | 1 | 7.08 |
| CHEMBL3747907 | — | — | 1 | 6.89 |
| CHEMBL3323053 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4173258 | — | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL14638 | CIPROXIFAN | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL3323035 | — | Ki | = | 76.2 | nM | 7.12 |
| CHEMBL1929421 | — | Ki | = | 84.2 | nM | 7.08 |
| CHEMBL3747907 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL3323053 | — | Ki | = | 2500.0 | nM | 5.60 |