Assay Detail
Functional
CHEMBL4337229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HCT116 cells assessed as cell growth inhibition after 72 hrs by alamar blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Molecular Networking for the Target Discovery of Oxahomoaporphine and 8-Oxohomoaporphine Alkaloids from <i>Duguetia surinamensis</i>.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.51 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.52 |
| CHEMBL4474927 | — | — | 1 | 5.40 |
| CHEMBL464748 | DICENTRINE | — | 1 | 5.06 |
| CHEMBL4564445 | — | — | 1 | 5.04 |
| CHEMBL4444630 | — | — | 1 | - |
| CHEMBL1668605 | 1,2,4-TRIMETHOXYBENZENE | — | 1 | - |
| CHEMBL4543133 | — | — | 1 | - |
| CHEMBL4575961 | — | — | 1 | - |
| CHEMBL4468022 | — | — | 1 | - |
| CHEMBL463284 | DICENTRINONE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4474927 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL464748 | DICENTRINE | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL4564445 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4444630 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1668605 | 1,2,4-TRIMETHOXYBENZENE | IC50 | > | 10000.0 | nM | - |
| CHEMBL4543133 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4575961 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4468022 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL463284 | DICENTRINONE | IC50 | > | 10000.0 | nM | - |