Assay Detail
Binding
CHEMBL4337249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as substrate in presence of MnSO4 incubated for 60 mins by o-phthaldialdehyde/N-(1-naphthyl)ethylene-diamine dihydrochloride reagent based colorimetric assay
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of <i>N</i>-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 7.05 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4538713 | — | — | 1 | 8.89 |
| CHEMBL4450972 | — | — | 1 | 8.60 |
| CHEMBL4557975 | — | — | 1 | 8.59 |
| CHEMBL4518246 | — | — | 1 | 8.11 |
| CHEMBL4594157 | — | — | 1 | 8.00 |
| CHEMBL4572850 | — | — | 1 | 8.00 |
| CHEMBL4461464 | — | — | 1 | 8.00 |
| CHEMBL4578964 | — | — | 1 | 7.96 |
| CHEMBL4530103 | — | — | 1 | 7.80 |
| CHEMBL4459462 | — | — | 1 | 7.75 |
| CHEMBL4556601 | — | — | 1 | 7.72 |
| CHEMBL4434802 | — | — | 1 | 7.52 |
| CHEMBL4573202 | — | — | 1 | 7.00 |
| CHEMBL4553794 | — | — | 1 | 6.96 |
| CHEMBL4440992 | — | — | 1 | 6.68 |
| CHEMBL4576356 | — | — | 1 | 6.52 |
| CHEMBL4590074 | — | — | 1 | 6.47 |
| CHEMBL4461151 | — | — | 1 | 6.44 |
| CHEMBL4457401 | — | — | 1 | 6.42 |
| CHEMBL4546530 | — | — | 2 | 6.42 |
| CHEMBL4565795 | — | — | 1 | 6.41 |
| CHEMBL4547509 | — | — | 1 | 6.40 |
| CHEMBL4469486 | — | — | 1 | 6.33 |
| CHEMBL4444238 | — | — | 1 | 6.22 |
| CHEMBL4467506 | — | — | 1 | 6.17 |
| CHEMBL1234777 | NOR-NOHA | 1.0 | 1 | 5.87 |
| CHEMBL1812661 | — | — | 1 | 5.81 |
| CHEMBL4514628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4538713 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4450972 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4557975 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4518246 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL4594157 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4572850 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4461464 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4578964 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4530103 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4459462 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4556601 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4434802 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4573202 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4553794 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4440992 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4576356 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4590074 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4461151 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4457401 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4546530 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4565795 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4547509 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4469486 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4444238 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4467506 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL1234777 | NOR-NOHA | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL1812661 | — | IC50 | = | 1547.0 | nM | 5.81 |
| CHEMBL4546530 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL4514628 | — | IC50 | - | — | - |