Compound Detail
CHEMBL4573202
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Basic Information
| ChEMBL ID | CHEMBL4573202 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QYTBWEJMHPQCLS-GWCFXTLKSA-N |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
310.2
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Arginase-1 CHEMBL1075097 | IC50 | 7.0 | 6.6333 | 100.0 | 3 |
| Unchecked CHEMBL612545 | IC50 | 6.48 | 6.48 | 330.0 | 1 |
| Arginase-2, mitochondrial CHEMBL1795148 | IC50 | 6.2 | 5.95 | 625.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Arginase-1 | IC50 | = | 100.0 | nM | 7.0 | Inhibition of human recombinant arginase 1 expressed in Escherichia coli BL21 (D... | 31408339 |
| Arginase-1 | IC50 | = | 125.0 | nM | 6.9 | Inhibition of Arginase: Inhibition of arginase I (ARG I) and arginase II (ARG II... | - |
| Unchecked | IC50 | = | 330.0 | nM | 6.48 | Inhibition of human recombinant arginase 2 H331 to I354 deletion mutant expresse... | 31408339 |
| Arginase-2, mitochondrial | IC50 | = | 625.0 | nM | 6.2 | Inhibition Assay of Arginase: Inhibition of arginase I (ARG I) and arginase II (... | - |
| Arginase-1 | IC50 | = | 1000.0 | nM | 6.0 | Inhibition Assay: Inhibition of arginase I (ARG I) and arginase II (ARG II) by F... | - |
| Arginase-2, mitochondrial | IC50 | = | 2000.0 | nM | 5.7 | Inhibition Assay: Inhibition of arginase I (ARG I) and arginase II (ARG II) by F... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31408339 | 10.1021/acs.jmedchem.9b00931 | Unchecked | 2 |
| 31408339 | 10.1021/acs.jmedchem.9b00931 | Arginase-1 | 1 |
Data from ChEMBL 36 via Core Engine