Assay Detail
Binding
CHEMBL4337250
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Inhibition of human recombinant arginase 2 H331 to I354 deletion mutant expressed in Escherichia coli BL21 (DE3) assessed as reduction in urea production using L-arginine as substrate in presence of MnSO4 incubated for 60 mins by colorimetric assay
29
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of <i>N</i>-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.54 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4538713 | — | — | 1 | 8.09 |
| CHEMBL4450972 | — | — | 1 | 8.02 |
| CHEMBL4557975 | — | — | 1 | 7.85 |
| CHEMBL4518246 | — | — | 1 | 7.80 |
| CHEMBL4572850 | — | — | 1 | 7.57 |
| CHEMBL4461464 | — | — | 1 | 7.57 |
| CHEMBL4594157 | — | — | 1 | 7.43 |
| CHEMBL4530103 | — | — | 1 | 7.43 |
| CHEMBL4578964 | — | — | 1 | 7.33 |
| CHEMBL4459462 | — | — | 1 | 7.21 |
| CHEMBL4556601 | — | — | 1 | 7.19 |
| CHEMBL4434802 | — | — | 1 | 7.02 |
| CHEMBL4573202 | — | — | 1 | 6.48 |
| CHEMBL4553794 | — | — | 1 | 6.36 |
| CHEMBL4440992 | — | — | 1 | 6.20 |
| CHEMBL4461151 | — | — | 1 | 6.07 |
| CHEMBL4457401 | — | — | 1 | 5.90 |
| CHEMBL1234777 | NOR-NOHA | 1.0 | 1 | 5.90 |
| CHEMBL4546530 | — | — | 2 | 5.89 |
| CHEMBL4469486 | — | — | 1 | 5.86 |
| CHEMBL4576356 | — | — | 1 | 5.81 |
| CHEMBL4565795 | — | — | 1 | 5.79 |
| CHEMBL4444238 | — | — | 1 | 5.73 |
| CHEMBL4467506 | — | — | 1 | 5.67 |
| CHEMBL4547509 | — | — | 1 | 5.66 |
| CHEMBL4590074 | — | — | 1 | 5.65 |
| CHEMBL1812661 | — | — | 1 | 5.59 |
| CHEMBL4514628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4538713 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL4450972 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL4557975 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4518246 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4572850 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4461464 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4594157 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4530103 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4578964 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4459462 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4556601 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4434802 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4573202 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4553794 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4440992 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4461151 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL1234777 | NOR-NOHA | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL4457401 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4546530 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL4469486 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4576356 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL4565795 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4444238 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL4467506 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL4547509 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL4590074 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL1812661 | — | IC50 | = | 2551.0 | nM | 5.59 |
| CHEMBL4546530 | — | IC50 | = | 79200.0 | nM | 4.10 |
| CHEMBL4514628 | — | IC50 | - | — | - |