Assay Detail
Binding
CHEMBL4337360
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Binding affinity to P38alpha MAPK (unknown origin) assessed as dissociation constant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent p38α MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 8.59 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1091199 | — | — | 1 | 9.52 |
| CHEMBL1938764 | — | — | 1 | 8.48 |
| CHEMBL3086685 | — | — | 1 | 7.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1091199 | — | Kd | = | 0.3 | nM | 9.52 |
| CHEMBL1938764 | — | Kd | = | 3.3 | nM | 8.48 |
| CHEMBL3086685 | — | Kd | = | 17.0 | nM | 7.77 |