Assay Detail
Binding
CHEMBL4337366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Pseudomonas aeruginosa LecB by fluorescence polarization assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Fucose-binding lectin PA-IIL (CHEMBL4523938) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Publication
Glycocluster Tetrahydroxamic Acids Exhibiting Unprecedented Inhibition of <i>Pseudomonas aeruginosa</i> Biofilms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.14 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4515649 | — | — | 1 | 6.60 |
| CHEMBL4515315 | — | — | 1 | 6.30 |
| CHEMBL4554703 | — | — | 1 | 6.18 |
| CHEMBL1234282 | — | — | 1 | 6.08 |
| CHEMBL6067643 | L-FUCOSE | 3.0 | 1 | 5.56 |
| CHEMBL195368 | — | — | 1 | - |
| CHEMBL4587299 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4515649 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL4515315 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4554703 | — | IC50 | = | 664.0 | nM | 6.18 |
| CHEMBL1234282 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL6067643 | L-FUCOSE | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL195368 | — | IC50 | = | 157000.0 | nM | - |
| CHEMBL4587299 | — | IC50 | = | 146300.0 | nM | - |