Assay Detail
Binding
CHEMBL4337408
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Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
[<sup>3</sup>H]UR-DEBa176: A 2,4-Diaminopyrimidine-Type Radioligand Enabling Binding Studies at the Human, Mouse, and Rat Histamine H<sub>4</sub> Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 6.89 | 7.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4454158 | — | — | 1 | 7.78 |
| CHEMBL4439142 | — | — | 1 | 7.59 |
| CHEMBL4443126 | — | — | 1 | 7.53 |
| CHEMBL4455324 | — | — | 1 | 7.47 |
| CHEMBL4445423 | — | — | 1 | 6.84 |
| CHEMBL4437371 | — | — | 1 | 6.72 |
| CHEMBL4543119 | — | — | 1 | 6.48 |
| CHEMBL4518374 | — | — | 1 | 6.19 |
| CHEMBL90 | HISTAMINE | 4.0 | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4454158 | — | EC50 | = | 16.6 | nM | 7.78 |
| CHEMBL4439142 | — | EC50 | = | 25.7 | nM | 7.59 |
| CHEMBL4443126 | — | EC50 | = | 29.51 | nM | 7.53 |
| CHEMBL4455324 | — | EC50 | = | 33.88 | nM | 7.47 |
| CHEMBL4445423 | — | EC50 | = | 144.54 | nM | 6.84 |
| CHEMBL4437371 | — | EC50 | = | 190.55 | nM | 6.72 |
| CHEMBL4543119 | — | EC50 | = | 331.13 | nM | 6.48 |
| CHEMBL4518374 | — | EC50 | = | 645.65 | nM | 6.19 |
| CHEMBL90 | HISTAMINE | EC50 | = | 3715.35 | nM | 5.43 |