Assay Detail
Functional
CHEMBL4337669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against X4 tropic HIV-1 subtype-B 3B infected in human MT2 cells or CEMx174 5.25 M7 cells assessed as reduction in p24 Gag protein production at 24:1 compound to HP23 ratio measured at 4 days post-infection by ELISA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | HIV-1 group M |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and Biological Evaluation of <i>m</i>-Xylene Thioether-Stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled-Coil Fusion Complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.76 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474461 | — | — | 1 | 7.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474461 | — | EC50 | = | 17.3 | nM | 7.76 |