Assay Detail
Functional
CHEMBL4337742
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against T2635 resistant HIV1 LAI harboring Q66R mutant infected in human MT2 cells or CEMx174 5.25 M7 cells assessed as reduction in p24 Gag protein production at 12.5:1 ratio of compound to HP23 measured at 4 days post infection by ELISA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design and Biological Evaluation of <i>m</i>-Xylene Thioether-Stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled-Coil Fusion Complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.64 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474461 | — | — | 1 | 7.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474461 | — | EC50 | = | 22.9 | nM | 7.64 |