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Assay Detail

CHEMBL4338313

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania donovani MHOM/ET/67/HU3 promastigote after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Discovery and Pharmacological Studies of 4-Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis.
Manzano JI, Cueto-Díaz EJ, Olías-Molero AI, Perea A, Herraiz T, Torrado JJ, Alunda JM, Gamarro F, Dardonville C.
J Med Chem (2019) 62 : 10664 -10675
PubMed 31702921 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 6.72 7.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4098620 1 7.40
CHEMBL4455204 1 7.16
CHEMBL4540674 1 7.05
CHEMBL4250711 1 7.05
CHEMBL267345 AMPHOTERICIN B 4.0 1 6.89
CHEMBL4472812 1 6.75
CHEMBL4449078 1 6.55
CHEMBL4514901 1 6.48
CHEMBL125 MILTEFOSINE 4.0 1 5.19
CHEMBL4096176 1 -
CHEMBL4086675 1 -
CHEMBL4099534 1 -
CHEMBL4467808 1 -
CHEMBL4218451 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4098620 EC50 = 40.0 nM 7.40
CHEMBL4455204 EC50 = 70.0 nM 7.16
CHEMBL4540674 EC50 = 90.0 nM 7.05
CHEMBL4250711 EC50 = 90.0 nM 7.05
CHEMBL267345 AMPHOTERICIN B EC50 = 130.0 nM 6.89
CHEMBL4472812 EC50 = 180.0 nM 6.75
CHEMBL4449078 EC50 = 280.0 nM 6.55
CHEMBL4514901 EC50 = 330.0 nM 6.48
CHEMBL125 MILTEFOSINE EC50 = 6510.0 nM 5.19
CHEMBL4096176 EC50 < 200.0 nM -
CHEMBL4086675 EC50 < 200.0 nM -
CHEMBL4099534 EC50 < 1000.0 nM -
CHEMBL4467808 EC50 < 200.0 nM -
CHEMBL4218451 EC50 < 200.0 nM -