Assay Detail
Functional
CHEMBL4338315
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Antileishmanial activity against Leishmania donovani MHOM/ET/67/HU3 intracellular amastigotes infected in human THP1 cells after 96 hrs by prolong-gold antifade-reagent/DAPI staining based assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and Pharmacological Studies of 4-Hydroxyphenyl-Derived Phosphonium Salts Active in a Mouse Model of Visceral Leishmaniasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.60 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4455204 | — | — | 1 | 7.05 |
| CHEMBL4540674 | — | — | 1 | 7.00 |
| CHEMBL4449078 | — | — | 1 | 7.00 |
| CHEMBL4098620 | — | — | 1 | 6.96 |
| CHEMBL4472812 | — | — | 1 | 6.92 |
| CHEMBL4250711 | — | — | 1 | 6.82 |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.62 |
| CHEMBL4514901 | — | — | 1 | 6.46 |
| CHEMBL4086675 | — | — | 1 | 6.10 |
| CHEMBL4096176 | — | — | 1 | 6.10 |
| CHEMBL4237238 | — | — | 1 | 6.10 |
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 6.04 |
| CHEMBL4099534 | — | — | 1 | - |
| CHEMBL4537973 | — | — | 1 | - |
| CHEMBL4580463 | — | — | 1 | - |
| CHEMBL4205256 | — | — | 1 | - |
| CHEMBL4467808 | — | — | 1 | - |
| CHEMBL4218451 | — | — | 1 | - |
| CHEMBL4247258 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4455204 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4540674 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4449078 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4098620 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4472812 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4250711 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL4514901 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4086675 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4096176 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4237238 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL125 | MILTEFOSINE | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4099534 | — | EC50 | < | 200.0 | nM | - |
| CHEMBL4537973 | — | EC50 | < | 1000.0 | nM | - |
| CHEMBL4580463 | — | EC50 | < | 1000.0 | nM | - |
| CHEMBL4205256 | — | EC50 | < | 1000.0 | nM | - |
| CHEMBL4467808 | — | EC50 | < | 200.0 | nM | - |
| CHEMBL4218451 | — | EC50 | < | 200.0 | nM | - |
| CHEMBL4247258 | — | EC50 | < | 1000.0 | nM | - |