Assay Detail
Binding
CHEMBL4338384
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Cathepsin L assessed as inhibition constant using Cbz-Phe-Arg-AMC as substrate by fluorescence assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.53 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4584291 | — | — | 1 | 9.22 |
| CHEMBL4475066 | — | — | 1 | 8.82 |
| CHEMBL4587965 | — | — | 1 | 8.39 |
| CHEMBL4515298 | — | — | 1 | 8.28 |
| CHEMBL4437914 | — | — | 1 | 7.99 |
| CHEMBL4436812 | — | — | 1 | 7.83 |
| CHEMBL4566436 | — | — | 1 | 7.46 |
| CHEMBL4453415 | — | — | 1 | 7.33 |
| CHEMBL4456010 | — | — | 1 | 7.11 |
| CHEMBL4454883 | — | — | 1 | 7.04 |
| CHEMBL4459413 | — | — | 1 | 6.97 |
| CHEMBL4456727 | — | — | 1 | 6.80 |
| CHEMBL4464737 | — | — | 1 | 6.76 |
| CHEMBL4441635 | — | — | 1 | 6.64 |
| CHEMBL4438444 | — | — | 1 | 6.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4584291 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL4475066 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL4587965 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL4515298 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL4437914 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL4436812 | — | Ki | = | 14.8 | nM | 7.83 |
| CHEMBL4566436 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL4453415 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL4456010 | — | Ki | = | 78.2 | nM | 7.11 |
| CHEMBL4454883 | — | Ki | = | 90.3 | nM | 7.04 |
| CHEMBL4459413 | — | Ki | = | 108.2 | nM | 6.97 |
| CHEMBL4456727 | — | Ki | = | 158.3 | nM | 6.80 |
| CHEMBL4464737 | — | Ki | = | 174.8 | nM | 6.76 |
| CHEMBL4441635 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL4438444 | — | Ki | = | 453.0 | nM | 6.34 |