Assay Detail
Functional
CHEMBL4338725
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Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Pyrazolyl-dihydroisoquinolines as Positive Allosteric Modulator of the Dopamine D1 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 7.15 | 7.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464150 | — | — | 1 | 7.87 |
| CHEMBL4468760 | — | — | 1 | 7.79 |
| CHEMBL4536851 | — | — | 1 | 7.74 |
| CHEMBL4449549 | — | — | 1 | 7.55 |
| CHEMBL4464215 | — | — | 1 | 7.09 |
| CHEMBL4449550 | — | — | 1 | 6.95 |
| CHEMBL4590150 | — | — | 1 | 6.90 |
| CHEMBL4573538 | — | — | 1 | 6.76 |
| CHEMBL4559891 | — | — | 1 | 6.54 |
| CHEMBL4465386 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464150 | — | EC50 | = | 13.4 | nM | 7.87 |
| CHEMBL4468760 | — | EC50 | = | 16.4 | nM | 7.79 |
| CHEMBL4536851 | — | EC50 | = | 18.3 | nM | 7.74 |
| CHEMBL4449549 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4464215 | — | EC50 | = | 81.2 | nM | 7.09 |
| CHEMBL4449550 | — | EC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4590150 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4573538 | — | EC50 | = | 172.0 | nM | 6.76 |
| CHEMBL4559891 | — | EC50 | = | 287.0 | nM | 6.54 |
| CHEMBL4465386 | — | EC50 | = | 540.0 | nM | 6.27 |