Assay Detail
Binding
CHEMBL4338771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of kinase tracer 178 binding to recombinant human His-tagged DDR1 expressed in baculovirus infected Sf9 cells incubated for 1 hr by TR-FRET based LanthaScreen Eu kinase binding assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Epithelial discoidin domain-containing receptor 1 (CHEMBL5319) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of VU6015929: A Selective Discoidin Domain Receptor 1/2 (DDR1/2) Inhibitor to Explore the Role of DDR1 in Antifibrotic Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.04 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4439970 | — | — | 1 | 8.40 |
| CHEMBL4539920 | — | — | 1 | 8.33 |
| CHEMBL4467377 | — | — | 1 | 8.23 |
| CHEMBL4546339 | — | — | 1 | 8.07 |
| CHEMBL4447700 | — | — | 1 | 7.98 |
| CHEMBL4584937 | — | — | 1 | 7.82 |
| CHEMBL4483465 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4439970 | — | IC50 | = | 3.97 | nM | 8.40 |
| CHEMBL4539920 | — | IC50 | = | 4.67 | nM | 8.33 |
| CHEMBL4467377 | — | IC50 | = | 5.89 | nM | 8.23 |
| CHEMBL4546339 | — | IC50 | = | 8.53 | nM | 8.07 |
| CHEMBL4447700 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL4584937 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL4483465 | — | IC50 | = | 36.4 | nM | 7.44 |