Assay Detail
Binding
CHEMBL4339337
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Inhibition of recombinant human AChE using acetylthiocholine iodide as substrate pre-incubated for 20 mins before substrate addition and measured for 180 secs by spectrophotometry based Ellman's method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.86 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4458648 | — | — | 1 | 6.66 |
| CHEMBL4525409 | — | — | 1 | 6.53 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.38 |
| CHEMBL4435178 | — | — | 1 | 6.24 |
| CHEMBL4580216 | — | — | 1 | 6.21 |
| CHEMBL4435058 | — | — | 1 | 6.11 |
| CHEMBL4445026 | — | — | 1 | 6.05 |
| CHEMBL4459154 | — | — | 1 | 6.02 |
| CHEMBL4466829 | — | — | 1 | 5.98 |
| CHEMBL4441059 | — | — | 1 | 5.98 |
| CHEMBL4444030 | — | — | 1 | 5.96 |
| CHEMBL4447258 | — | — | 1 | 5.84 |
| CHEMBL4553902 | — | — | 1 | 5.64 |
| CHEMBL4542112 | — | — | 1 | 5.56 |
| CHEMBL4592037 | — | — | 1 | 5.43 |
| CHEMBL4557164 | — | — | 1 | 5.39 |
| CHEMBL4556651 | — | — | 1 | 5.24 |
| CHEMBL4443988 | — | — | 1 | 5.15 |
| CHEMBL4526428 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4458648 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL4525409 | — | IC50 | = | 293.0 | nM | 6.53 |
| CHEMBL95 | TACRINE | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL4435178 | — | IC50 | = | 571.0 | nM | 6.24 |
| CHEMBL4580216 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL4435058 | — | IC50 | = | 786.0 | nM | 6.11 |
| CHEMBL4445026 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4459154 | — | IC50 | = | 961.0 | nM | 6.02 |
| CHEMBL4466829 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4441059 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4444030 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL4447258 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL4553902 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4542112 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL4592037 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL4557164 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4556651 | — | IC50 | = | 5770.0 | nM | 5.24 |
| CHEMBL4443988 | — | IC50 | = | 7030.0 | nM | 5.15 |
| CHEMBL4526428 | — | IC50 | = | 12800.0 | nM | 4.89 |