Assay Detail
Functional
CHEMBL4339444
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Potentiation of daunorubicin-induced cytotoxicity against human HL60 cells assessed as daunorubicin IC50 pretreated for 24 hrs followed by daunorubicin addition and measured after 72 hrs by cellTiter 96 aqueous one solution reagent based assay (Rvb = 0.05 uM)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.74 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470997 | — | — | 1 | 8.00 |
| CHEMBL4473138 | — | — | 1 | 7.70 |
| CHEMBL4467986 | — | — | 1 | 7.52 |
| CHEMBL511708 | BACCHARIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470997 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4473138 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4467986 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL511708 | BACCHARIN | IC50 | < | 10.0 | nM | - |