Assay Detail
Binding
CHEMBL4339656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor measured after 2 hrs by liquid scintillation counting analysis
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 2B (CHEMBL311) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 7.55 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4443868 | — | — | 1 | 8.48 |
| CHEMBL4529074 | — | — | 1 | 8.37 |
| CHEMBL4547576 | — | — | 1 | 8.29 |
| CHEMBL4550955 | — | — | 1 | 8.11 |
| CHEMBL4445829 | — | — | 1 | 8.00 |
| CHEMBL4302264 | — | — | 1 | 7.96 |
| CHEMBL4474982 | — | — | 1 | 7.92 |
| CHEMBL4571666 | — | — | 1 | 7.82 |
| CHEMBL4515350 | — | — | 1 | 7.82 |
| CHEMBL4531750 | — | — | 1 | 7.80 |
| CHEMBL4593473 | — | — | 1 | 7.60 |
| CHEMBL4211247 | — | — | 1 | 7.57 |
| CHEMBL4588774 | — | — | 1 | 7.46 |
| CHEMBL4575739 | — | — | 1 | 7.44 |
| CHEMBL4451099 | — | — | 1 | 7.39 |
| CHEMBL4451514 | — | — | 1 | 7.34 |
| CHEMBL4529810 | — | — | 1 | 7.28 |
| CHEMBL4591770 | — | — | 1 | 7.27 |
| CHEMBL4539619 | — | — | 1 | 7.18 |
| CHEMBL4446706 | — | — | 1 | 7.12 |
| CHEMBL4471014 | — | — | 1 | 7.11 |
| CHEMBL4467491 | — | — | 1 | 7.10 |
| CHEMBL4590530 | — | — | 1 | 7.06 |
| CHEMBL4475155 | — | — | 1 | 7.00 |
| CHEMBL4464756 | — | — | 1 | 6.96 |
| CHEMBL4526512 | — | — | 1 | 6.93 |
| CHEMBL4537967 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4443868 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL4529074 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL4547576 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4550955 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL4445829 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL4302264 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4474982 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4571666 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL4515350 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL4531750 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4593473 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4211247 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL4588774 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL4575739 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL4451099 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL4451514 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL4529810 | — | Ki | = | 52.0 | nM | 7.28 |
| CHEMBL4591770 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL4539619 | — | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL4446706 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL4471014 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL4467491 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL4590530 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL4475155 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4464756 | — | Ki | = | 109.0 | nM | 6.96 |
| CHEMBL4526512 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL4537967 | — | Ki | - | — | - |