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Assay Detail

CHEMBL4339813

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against ENV pseudotyped HIV1 JFRL infected in human HeLa67 cells expressing CD4/CCR5/CXCR5 after 72 hrs by luciferase reporter gene assay
ChEMBL ↗
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

A survey of core replacements in indole-based HIV-1 attachment inhibitors.
Wang T, Wallace OB, Zhang Z, Fang H, Yang Z, Robinson BA, Spicer TP, Gong YF, Blair WS, Shi PY, Lin PF, Deshpande M, Meanwell NA, Kadow JF.
Bioorg Med Chem Lett (2019) 29 : 1423 -1429
PubMed 30940396 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 60 7.55 10.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4460806 — — 1 10.52
CHEMBL3301620 TEMSAVIR 2.0 1 10.00
CHEMBL4458358 — — 1 10.00
CHEMBL4465368 — — 1 9.80
CHEMBL4559077 — — 1 9.70
CHEMBL4533029 — — 1 9.70
CHEMBL4450106 — — 1 9.40
CHEMBL4442728 — — 1 9.15
CHEMBL4521757 — — 1 8.92
CHEMBL4470328 — — 1 8.89
CHEMBL4528303 — — 1 8.77
CHEMBL4539272 — — 1 8.62
CHEMBL4473819 — — 1 8.59
CHEMBL4474300 — — 1 8.54
CHEMBL567570 — — 1 8.40
CHEMBL4464807 — — 1 8.36
CHEMBL4592211 — — 1 8.34
CHEMBL4582105 — — 1 8.32
CHEMBL4572699 — — 1 8.23
CHEMBL4475380 — — 1 7.96
CHEMBL4459896 — — 1 7.92
CHEMBL4442710 — — 1 7.92
CHEMBL4469063 — — 1 7.89
CHEMBL4459020 — — 1 7.77
CHEMBL4455463 — — 1 7.58
CHEMBL4517817 — — 1 7.57
CHEMBL4466315 — — 1 7.52
CHEMBL4564091 — — 1 7.47
CHEMBL4448182 — — 1 7.28
CHEMBL4580617 — — 1 7.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4460806 — EC50 = 0.03 nM 10.52
CHEMBL3301620 TEMSAVIR EC50 = 0.1 nM 10.00
CHEMBL4458358 — EC50 = 0.1 nM 10.00
CHEMBL4465368 — EC50 = 0.16 nM 9.80
CHEMBL4559077 — EC50 = 0.2 nM 9.70
CHEMBL4533029 — EC50 = 0.2 nM 9.70
CHEMBL4450106 — EC50 = 0.4 nM 9.40
CHEMBL4442728 — EC50 = 0.7 nM 9.15
CHEMBL4521757 — EC50 = 1.2 nM 8.92
CHEMBL4470328 — EC50 = 1.3 nM 8.89
CHEMBL4528303 — EC50 = 1.7 nM 8.77
CHEMBL4539272 — EC50 = 2.4 nM 8.62
CHEMBL4473819 — EC50 = 2.6 nM 8.59
CHEMBL4474300 — EC50 = 2.9 nM 8.54
CHEMBL567570 — EC50 = 4.0 nM 8.40
CHEMBL4464807 — EC50 = 4.4 nM 8.36
CHEMBL4592211 — EC50 = 4.6 nM 8.34
CHEMBL4582105 — EC50 = 4.8 nM 8.32
CHEMBL4572699 — EC50 = 5.9 nM 8.23
CHEMBL4475380 — EC50 = 11.0 nM 7.96
CHEMBL4459896 — EC50 = 11.9 nM 7.92
CHEMBL4442710 — EC50 = 12.0 nM 7.92
CHEMBL4469063 — EC50 = 13.0 nM 7.89
CHEMBL4459020 — EC50 = 17.0 nM 7.77
CHEMBL4455463 — EC50 = 26.0 nM 7.58
CHEMBL4517817 — EC50 = 27.0 nM 7.57
CHEMBL4466315 — EC50 = 30.0 nM 7.52
CHEMBL4564091 — EC50 = 34.0 nM 7.47
CHEMBL4448182 — EC50 = 52.0 nM 7.28
CHEMBL4580617 — EC50 = 56.0 nM 7.25
CHEMBL4451967 — EC50 = 86.0 nM 7.07
CHEMBL4443199 — EC50 = 108.0 nM 6.97
CHEMBL4515136 — EC50 = 135.0 nM 6.87
CHEMBL4466199 — EC50 = 137.0 nM 6.86
CHEMBL336293 — EC50 = 153.0 nM 6.82
CHEMBL4458980 — EC50 = 182.0 nM 6.74
CHEMBL573941 — EC50 = 219.0 nM 6.66
CHEMBL4475982 — EC50 = 255.0 nM 6.59
CHEMBL4533962 — EC50 = 355.0 nM 6.45
CHEMBL4444338 — EC50 = 358.0 nM 6.45
CHEMBL4470085 — EC50 = 407.0 nM 6.39
CHEMBL4444470 — EC50 = 561.0 nM 6.25
CHEMBL4585716 — EC50 = 655.0 nM 6.18
CHEMBL4461429 — EC50 = 734.0 nM 6.13
CHEMBL4441372 — EC50 = 764.0 nM 6.12
CHEMBL4520493 — EC50 = 798.0 nM 6.10
CHEMBL4580178 — EC50 = 1006.0 nM 6.00
CHEMBL4443584 — EC50 = 2324.0 nM 5.63
CHEMBL4460976 — EC50 = 2460.0 nM 5.61
CHEMBL4465818 — EC50 = 2838.0 nM 5.55