Assay Detail
Functional
CHEMBL4339970
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Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical synthesis, microbial transformation and biological evaluation of tetrahydroprotoberberines as dopamine D1/D2 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.14 | 8.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 1 | 8.47 |
| CHEMBL4438471 | — | — | 1 | 6.41 |
| CHEMBL2314745 | — | — | 1 | 6.39 |
| CHEMBL2314747 | — | — | 1 | 6.20 |
| CHEMBL4521450 | — | — | 1 | 6.17 |
| CHEMBL4582377 | — | — | 1 | 5.99 |
| CHEMBL2314734 | — | — | 1 | 5.97 |
| CHEMBL4476383 | — | — | 1 | 5.85 |
| CHEMBL487182 | TETRAHYDROPALMATINE | 2.0 | 1 | 5.79 |
| CHEMBL4561303 | — | — | 1 | 5.19 |
| CHEMBL4544045 | — | — | 1 | 5.13 |
| CHEMBL2314740 | — | — | 1 | - |
| CHEMBL4453330 | — | — | 1 | - |
| CHEMBL4551037 | — | — | 1 | - |
| CHEMBL4435291 | — | — | 1 | - |
| CHEMBL2314741 | — | — | 1 | - |
| CHEMBL2314742 | — | — | 1 | - |
| CHEMBL4528264 | — | — | 1 | - |
| CHEMBL4585730 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4438471 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL2314745 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2314747 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4521450 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4582377 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL2314734 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4476383 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL487182 | TETRAHYDROPALMATINE | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4561303 | — | IC50 | = | 6510.0 | nM | 5.19 |
| CHEMBL4544045 | — | IC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL2314740 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4453330 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4551037 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4435291 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2314741 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2314742 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4528264 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4585730 | — | IC50 | > | 10000.0 | nM | - |