Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4339977

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of FGFR4 (unknown origin) incubated for 60 mins by caliper microfluidic mobility shift technology based assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fibroblast growth factor receptor 4 (CHEMBL3973)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel 7-formyl-naphthyridyl-ureas derivatives as potential selective FGFR4 inhibitors: Design, synthesis, and biological activity studies.
Sun C, Fang L, Zhang X, Gao P, Gou S.
Bioorg Med Chem (2019) 27 : 1932 -1941
PubMed 30987781 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 8.43 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4457168 1 9.00
CHEMBL4439119 1 9.00
CHEMBL4518346 1 8.92
CHEMBL4533697 1 8.89
CHEMBL4562284 1 8.89
CHEMBL4532389 1 8.85
CHEMBL4475216 1 8.82
CHEMBL3968334 1 8.80
CHEMBL4446965 1 8.77
CHEMBL3908979 FGF401 2.0 1 8.72
CHEMBL4446464 1 8.68
CHEMBL4553307 1 8.57
CHEMBL4571626 1 8.46
CHEMBL4556198 1 8.35
CHEMBL4564505 1 8.34
CHEMBL4587476 1 8.34
CHEMBL4470137 1 8.33
CHEMBL4544586 1 8.30
CHEMBL4472588 1 8.28
CHEMBL4471457 1 8.12
CHEMBL4441426 1 8.04
CHEMBL4447090 1 8.03
CHEMBL4471404 1 8.02
CHEMBL4469046 1 7.96
CHEMBL4533002 1 7.42
CHEMBL4476676 1 7.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4457168 IC50 = 1.0 nM 9.00
CHEMBL4439119 IC50 = 1.0 nM 9.00
CHEMBL4518346 IC50 = 1.2 nM 8.92
CHEMBL4533697 IC50 = 1.3 nM 8.89
CHEMBL4562284 IC50 = 1.3 nM 8.89
CHEMBL4532389 IC50 = 1.4 nM 8.85
CHEMBL4475216 IC50 = 1.5 nM 8.82
CHEMBL3968334 IC50 = 1.6 nM 8.80
CHEMBL4446965 IC50 = 1.7 nM 8.77
CHEMBL3908979 FGF401 IC50 = 1.9 nM 8.72
CHEMBL4446464 IC50 = 2.1 nM 8.68
CHEMBL4553307 IC50 = 2.7 nM 8.57
CHEMBL4571626 IC50 = 3.5 nM 8.46
CHEMBL4556198 IC50 = 4.5 nM 8.35
CHEMBL4564505 IC50 = 4.6 nM 8.34
CHEMBL4587476 IC50 = 4.6 nM 8.34
CHEMBL4470137 IC50 = 4.7 nM 8.33
CHEMBL4544586 IC50 = 5.0 nM 8.30
CHEMBL4472588 IC50 = 5.3 nM 8.28
CHEMBL4471457 IC50 = 7.5 nM 8.12
CHEMBL4441426 IC50 = 9.1 nM 8.04
CHEMBL4447090 IC50 = 9.4 nM 8.03
CHEMBL4471404 IC50 = 9.5 nM 8.02
CHEMBL4469046 IC50 = 11.1 nM 7.96
CHEMBL4533002 IC50 = 38.0 nM 7.42
CHEMBL4476676 IC50 = 71.0 nM 7.15