Assay Detail
Functional
CHEMBL4339979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HuH7 cells with high FGFR4 expression assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo method
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel 7-formyl-naphthyridyl-ureas derivatives as potential selective FGFR4 inhibitors: Design, synthesis, and biological activity studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.74 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475216 | — | — | 1 | 8.60 |
| CHEMBL4439119 | — | — | 1 | 8.57 |
| CHEMBL4446464 | — | — | 1 | 8.34 |
| CHEMBL4562284 | — | — | 1 | 8.31 |
| CHEMBL4457168 | — | — | 1 | 8.27 |
| CHEMBL4532389 | — | — | 1 | 8.14 |
| CHEMBL4533697 | — | — | 1 | 8.11 |
| CHEMBL4518346 | — | — | 1 | 8.08 |
| CHEMBL4446965 | — | — | 1 | 8.05 |
| CHEMBL4470137 | — | — | 1 | 7.99 |
| CHEMBL4564505 | — | — | 1 | 7.93 |
| CHEMBL3908979 | FGF401 | 2.0 | 1 | 7.79 |
| CHEMBL3968334 | — | — | 1 | 7.76 |
| CHEMBL4533002 | — | — | 1 | 7.68 |
| CHEMBL4571626 | — | — | 1 | 7.56 |
| CHEMBL4471404 | — | — | 1 | 7.53 |
| CHEMBL4587476 | — | — | 1 | 7.49 |
| CHEMBL4469046 | — | — | 1 | 7.46 |
| CHEMBL4472588 | — | — | 1 | 7.44 |
| CHEMBL4544586 | — | — | 1 | 7.39 |
| CHEMBL4553307 | — | — | 1 | 7.39 |
| CHEMBL4471457 | — | — | 1 | 7.30 |
| CHEMBL4556198 | — | — | 1 | 7.29 |
| CHEMBL4441426 | — | — | 1 | 7.18 |
| CHEMBL4476676 | — | — | 1 | 7.16 |
| CHEMBL4447090 | — | — | 1 | 6.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475216 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4439119 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4446464 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4562284 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4457168 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL4532389 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4533697 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL4518346 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL4446965 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4470137 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL4564505 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL3908979 | FGF401 | IC50 | = | 16.3 | nM | 7.79 |
| CHEMBL3968334 | — | IC50 | = | 17.3 | nM | 7.76 |
| CHEMBL4533002 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL4571626 | — | IC50 | = | 27.5 | nM | 7.56 |
| CHEMBL4471404 | — | IC50 | = | 29.6 | nM | 7.53 |
| CHEMBL4587476 | — | IC50 | = | 32.2 | nM | 7.49 |
| CHEMBL4469046 | — | IC50 | = | 34.6 | nM | 7.46 |
| CHEMBL4472588 | — | IC50 | = | 36.1 | nM | 7.44 |
| CHEMBL4544586 | — | IC50 | = | 40.5 | nM | 7.39 |
| CHEMBL4553307 | — | IC50 | = | 40.8 | nM | 7.39 |
| CHEMBL4471457 | — | IC50 | = | 50.1 | nM | 7.30 |
| CHEMBL4556198 | — | IC50 | = | 51.8 | nM | 7.29 |
| CHEMBL4441426 | — | IC50 | = | 65.3 | nM | 7.18 |
| CHEMBL4476676 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4447090 | — | IC50 | = | 297.0 | nM | 6.53 |