Assay Detail
Binding
CHEMBL4340235
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Competitive inhibition of recombinant GES-5 expressed in Escherichia coli BL21(DE3) using nitrocefin substrate by spectrophotometry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
X-ray Crystallography Deciphers the Activity of Broad-Spectrum Boronic Acid β-Lactamase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.22 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568968 | — | — | 1 | 6.80 |
| CHEMBL4535625 | — | — | 1 | 5.24 |
| CHEMBL4541975 | — | — | 1 | 5.05 |
| CHEMBL4466682 | — | — | 1 | 4.82 |
| CHEMBL4458371 | — | — | 1 | 4.77 |
| CHEMBL235073 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568968 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL4535625 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL4541975 | — | Ki | = | 8900.0 | nM | 5.05 |
| CHEMBL4466682 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL4458371 | — | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL235073 | — | Ki | = | 24000.0 | nM | 4.62 |