Compound Detail
CHEMBL235073
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Basic Information
| ChEMBL ID | CHEMBL235073 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GVTZPLCQJFQOTQ-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
263.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.43
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Beta-lactamase TEM CHEMBL2065 | Ki | 7.43 | 7.43 | 37.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 7.4 | 6.01 | 40.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Beta-lactamase TEM | Ki | = | 37.0 | nM | 7.43 | Inhibition of Escherichia coli beta-lactamase | 17956081 |
| Unchecked | Ki | = | 40.0 | nM | 7.4 | Inhibition of Pseudomonas aeruginosa AmpC expressed in Escherichia coli BL21(DE3... | 30996812 |
| Unchecked | Ki | = | 24000.0 | nM | 4.62 | Competitive inhibition of recombinant GES-5 expressed in Escherichia coli BL21(D... | 30996812 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30996812 | 10.1021/acsmedchemlett.8b00607 | Unchecked | 5 |
| 17956081 | 10.1021/jm070643q | No relevant target | 1 |
| 17956081 | 10.1021/jm070643q | Beta-lactamase TEM | 1 |
| 17956081 | 10.1021/jm070643q | Escherichia coli | 1 |
Data from ChEMBL 36 via Core Engine