Assay Detail
Binding
CHEMBL4340238
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Inhibition of Pseudomonas aeruginosa AmpC expressed in Escherichia coli BL21(DE3) using cephalothin as reporter substrate incubated for 300 secs by spectrophotometric assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
X-ray Crystallography Deciphers the Activity of Broad-Spectrum Boronic Acid β-Lactamase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.66 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL235073 | — | — | 1 | 7.40 |
| CHEMBL4466682 | — | — | 1 | 7.30 |
| CHEMBL4541975 | — | — | 1 | 7.16 |
| CHEMBL4568968 | — | — | 1 | 6.38 |
| CHEMBL4458371 | — | — | 1 | 5.89 |
| CHEMBL4535625 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL235073 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL4466682 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL4541975 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL4568968 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL4458371 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL4535625 | — | Ki | = | 1400.0 | nM | 5.85 |