Assay Detail
Binding
CHEMBL901565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Escherichia coli beta-lactamase
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimizing cell permeation of an antibiotic resistance inhibitor for improved efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 6.90 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396872 | — | — | 1 | 8.00 |
| CHEMBL34964 | — | — | 1 | 7.57 |
| CHEMBL235293 | — | — | 1 | 7.55 |
| CHEMBL235526 | — | — | 1 | 7.55 |
| CHEMBL238243 | — | — | 1 | 7.52 |
| CHEMBL397522 | — | — | 1 | 7.52 |
| CHEMBL235073 | — | — | 1 | 7.43 |
| CHEMBL235292 | — | — | 1 | 7.43 |
| CHEMBL395398 | — | — | 1 | 7.37 |
| CHEMBL235308 | — | — | 1 | 7.35 |
| CHEMBL236203 | — | — | 1 | 7.10 |
| CHEMBL395186 | — | — | 1 | 7.09 |
| CHEMBL237390 | — | — | 1 | 7.08 |
| CHEMBL235951 | — | — | 1 | 6.77 |
| CHEMBL235523 | — | — | 1 | 6.60 |
| CHEMBL396889 | — | — | 1 | 6.60 |
| CHEMBL396871 | — | — | 1 | 6.60 |
| CHEMBL396390 | — | — | 1 | 6.58 |
| CHEMBL235291 | — | — | 1 | 6.35 |
| CHEMBL237181 | — | — | 1 | 6.22 |
| CHEMBL391537 | — | — | 1 | 6.10 |
| CHEMBL235097 | — | — | 1 | 6.00 |
| CHEMBL398112 | — | — | 1 | 5.70 |
| CHEMBL236759 | — | — | 1 | 5.60 |
| CHEMBL235524 | — | — | 1 | - |
| CHEMBL235508 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396872 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL34964 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL235293 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL235526 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL238243 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL397522 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL235073 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL235292 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL395398 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL235308 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL236203 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL395186 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL237390 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL235951 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL235523 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL396889 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL396871 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL396390 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL235291 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL237181 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL391537 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL235097 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL398112 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL236759 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL235524 | — | Ki | - | — | - | |
| CHEMBL235508 | — | Ki | - | — | - |