Assay Detail
Functional
CHEMBL4340335
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Cytotoxicity in human SNB19 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNB-19 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ascomylactams A-C, Cytotoxic 12- or 13-Membered-Ring Macrocyclic Alkaloids Isolated from the Mangrove Endophytic Fungus Didymella sp. CYSK-4, and Structure Revisions of Phomapyrrolidones A and C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.04 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417 | EPIRUBICIN | 4.0 | 1 | 5.64 |
| CHEMBL4582938 | — | — | 1 | 5.17 |
| CHEMBL4464212 | — | — | 1 | 5.11 |
| CHEMBL4447474 | — | — | 1 | 4.75 |
| CHEMBL4469905 | — | — | 1 | 4.54 |
| CHEMBL4449755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417 | EPIRUBICIN | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4582938 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4464212 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4447474 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4469905 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4449755 | — | IC50 | > | 50000.0 | nM | - |