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Compound Detail

CHEMBL4447474

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CC1=C[C@@]2(C)C(=C(C)[C@H]3[C@@H]4C[C@H](C)C[C@H](C)[C@H]4[C@@H]4Oc5ccc(cc5)C[C@@]5(O)C=C(C(=O)N5)C(=O)[C@@H]2[C@@H]43)[C@H]1C

Basic Information

ChEMBL ID CHEMBL4447474
Phase Preclinical
Structure Type MOL
InChI Key LLDBYBFRGSYHAF-YSCVJVDNSA-N
9
Targets
9
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

527.7
MW (Da)
5.40
ALogP
4
HBA
2
HBD
75.6
PSA (Ų)
0.35
QED
2
Ro5 Violations
0
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C34H41NO4
MW 527.71
Aromatic Rings 1
Heavy Atoms 39
NP-Likeness 2.31

Activity Summary

IC50 9 meas. best 5.35

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
HCT-116
CHEMBL394
IC50 5.35 5.35 4500.0 1
MDA-MB-231
CHEMBL400
IC50 5.18 5.18 6600.0 1
Receptor-type tyrosine-protein phosphatase S
CHEMBL2396508
IC50 5.08 5.08 8400.0 1
Tyrosine-protein phosphatase non-receptor type 1
CHEMBL335
IC50 4.96 4.96 11000.0 1
MDA-MB-435
CHEMBL614697
IC50 4.92 4.92 12000.0 1
NCI-H460
CHEMBL396
IC50 4.89 4.89 13000.0 1
SNB-19
CHEMBL614164
IC50 4.75 4.75 18000.0 1
PC-3
CHEMBL390
IC50 4.7 4.7 20000.0 1
Dual specificity protein phosphatase 3
CHEMBL2635
IC50 4.42 4.42 38000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
38427823 10.1021/acs.jnatprod.3c00984 Staphylococcus aureus 2
38427823 10.1021/acs.jnatprod.3c00984 Dual specificity protein phosphatase 3 1
38427823 10.1021/acs.jnatprod.3c00984 Candida albicans 1
38427823 10.1021/acs.jnatprod.3c00984 Paracidovorax citrulli 1
38427823 10.1021/acs.jnatprod.3c00984 Pseudomonas aeruginosa 1
38427823 10.1021/acs.jnatprod.3c00984 Micrococcus luteus 1
38427823 10.1021/acs.jnatprod.3c00984 Streptococcus iniae 1
38427823 10.1021/acs.jnatprod.3c00984 Bacillus amyloliquefaciens 1
38427823 10.1021/acs.jnatprod.3c00984 Streptococcus agalactiae 1
38427823 10.1021/acs.jnatprod.3c00984 Bacillus subtilis 1
38427823 10.1021/acs.jnatprod.3c00984 Escherichia coli 1
31251621 10.1021/acs.jnatprod.8b00918 MDA-MB-231 1
38427823 10.1021/acs.jnatprod.3c00984 Receptor-type tyrosine-protein phosphatase S 1
38427823 10.1021/acs.jnatprod.3c00984 Receptor-type tyrosine-protein phosphatase F 1
38427823 10.1021/acs.jnatprod.3c00984 M-phase inducer phosphatase 2 1
38427823 10.1021/acs.jnatprod.3c00984 Tyrosine-protein phosphatase non-receptor type 1 1
31251621 10.1021/acs.jnatprod.8b00918 PC-3 1
31251621 10.1021/acs.jnatprod.8b00918 NCI-H460 1
31251621 10.1021/acs.jnatprod.8b00918 HCT-116 1
31251621 10.1021/acs.jnatprod.8b00918 SNB-19 1

Data from ChEMBL 36 via Core Engine