Assay Detail
Functional
CHEMBL4340337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in human NCI-H460 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ascomylactams A-C, Cytotoxic 12- or 13-Membered-Ring Macrocyclic Alkaloids Isolated from the Mangrove Endophytic Fungus Didymella sp. CYSK-4, and Structure Revisions of Phomapyrrolidones A and C.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.33 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417 | EPIRUBICIN | 4.0 | 1 | 6.92 |
| CHEMBL4582938 | — | — | 1 | 5.36 |
| CHEMBL4464212 | — | — | 1 | 5.36 |
| CHEMBL4469905 | — | — | 1 | 4.92 |
| CHEMBL4447474 | — | — | 1 | 4.89 |
| CHEMBL4449755 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417 | EPIRUBICIN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4582938 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4464212 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4469905 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4447474 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4449755 | — | IC50 | = | 28000.0 | nM | 4.55 |