Assay Detail
Binding
CHEMBL4340711
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human OGFOD1 using 2OG as substrate and Fe2 as co-factor assessed as hydroxylation incubated for 15 mins in presence of L-ascorbate by MALDI-TOF MS analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of a viral prolyl hydroxylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.61 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3646221 | VADADUSTAT | 4.0 | 1 | 5.85 |
| CHEMBL4163812 | — | — | 1 | 5.68 |
| CHEMBL3646117 | — | — | 1 | 5.29 |
| CHEMBL3646118 | MOLIDUSTAT | 2.0 | 1 | - |
| CHEMBL2338329 | ROXADUSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3646221 | VADADUSTAT | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4163812 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3646117 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3646118 | MOLIDUSTAT | IC50 | < | 1000.0 | nM | - |
| CHEMBL2338329 | ROXADUSTAT | IC50 | < | 1000.0 | nM | - |