Assay Detail
Functional
CHEMBL4341004
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Vasodilating activity in Sprague-Dawley rat aortic rings assessed as reduction in phenylephrine-induced contractions at 1:1 ratio of test compound to furoxan
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dual-targeting Rutaecarpine-NO donor hybrids as novel anti-hypertensive agents by promoting release of CGRP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 7.53 | 7.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85139 | RUTAECARPINE | — | 1 | 7.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85139 | RUTAECARPINE | EC50 | = | 29.7 | nM | 7.53 |