Assay Detail
Functional
CHEMBL4341114
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against patient derived inflammatory breast cancer cell spheroids assessed as increase in spheroid dissolution incubated for 24 hrs by propidium iodide/Acridine orange staining based dual-fluorescence viability assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Breast carcinoma cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.89 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL555017 | GAMBOGIC ACID | — | 1 | 6.38 |
| CHEMBL1762708 | — | — | 1 | 6.18 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL555017 | GAMBOGIC ACID | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1762708 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 7800.0 | nM | 5.11 |