Assay Detail
Binding
CHEMBL4342661
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human acetylcholinesterase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.94 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 8.24 |
| CHEMBL4541077 | — | — | 1 | 7.58 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 7.52 |
| CHEMBL4536838 | — | — | 1 | 7.51 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.42 |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4541077 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL95 | TACRINE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4536838 | — | IC50 | = | 30.7 | nM | 7.51 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 4150.0 | nM | 5.38 |