Assay Detail
Binding
CHEMBL4342663
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat brain Acetylcholinesterase using acetylthiocholine as substrate in presence of BChE inhibitor ethopropazine by spectrophotometric method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.48 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32823 | — | — | 1 | 9.40 |
| CHEMBL75274 | — | — | 1 | 9.18 |
| CHEMBL424707 | — | — | 1 | 9.11 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32823 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL75274 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL424707 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL95 | TACRINE | IC50 | = | 590.0 | nM | 6.23 |