Assay Detail
Binding
CHEMBL4342716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human erythrocyte acetylcholinesterase using acetylthiocholine as substrate preincubated for 60 mins followed by substrate addition by Ellman's method
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.06 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356385 | — | — | 3 | 5.70 |
| CHEMBL4473282 | — | — | 1 | 4.36 |
| CHEMBL4579904 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356385 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL356385 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL356385 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4473282 | — | IC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL4579904 | — | IC50 | = | 52400.0 | nM | 4.28 |