Assay Detail
Binding
CHEMBL4344272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARalpha (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.61 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3707395 | ELAFIBRANOR | 4.0 | 1 | 8.00 |
| CHEMBL230158 | SELADELPAR | 4.0 | 1 | 5.82 |
| CHEMBL595 | PIOGLITAZONE | 4.0 | 1 | 5.17 |
| CHEMBL672 | FENOFIBRATE | 4.0 | 1 | 4.52 |
| CHEMBL981 | FENOFIBRIC ACID | 4.0 | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3707395 | ELAFIBRANOR | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL230158 | SELADELPAR | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL595 | PIOGLITAZONE | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL672 | FENOFIBRATE | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL981 | FENOFIBRIC ACID | EC50 | = | 30000.0 | nM | 4.52 |