Compound Detail
CHEMBL230158
SELADELPAR 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL230158 |
| Name | SELADELPAR |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | JWHYSEDOYMYMNM-QGZVFWFLSA-N |
| Therapeutic | ✓ Yes |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
10
Publications
4
Known Names
6
Indications
1
Mechanisms
Molecular Properties
444.5
MW (Da)
5.05
ALogP
5
HBA
1
HBD
65.0
PSA (Ų)
0.49
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2024 |
| Availability | Prescription |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Peroxisome proliferator-activated receptor delta agonist | AGONIST | Peroxisome proliferator-activated receptor delta | ✓ | ✓ |
Indications
Liver Cirrhosis, Biliary Cholangitis, Sclerosing Hyperlipidemias Hyperlipoproteinemia Type II Non-alcoholic Fatty Liver Disease Liver Diseases
ATC Classification
A05AX07
seladelpar
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: BILE AND LIVER THERAPY
Activity Summary
EC50 4 meas. best 8.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor delta CHEMBL3979 | EC50 | 8.72 | 8.7067 | 1.9 | 3 |
| Peroxisome proliferator-activated receptor alpha CHEMBL239 | EC50 | 5.82 | 5.82 | 1500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor delta | EC50 | = | 1.9 | nM | 8.72 | Agonist activity at human PPARdelta receptor by cell based transactivation assay | 17524639 |
| Peroxisome proliferator-activated receptor delta | EC50 | = | 2.0 | nM | 8.7 | Agonist activity at PPARdelta (unknown origin) | 31930920 |
| Peroxisome proliferator-activated receptor delta | EC50 | = | 2.0 | nM | 8.7 | Agonist activity at PPARdelta (unknown origin) | 32339855 |
| Peroxisome proliferator-activated receptor alpha | EC50 | = | 1500.0 | nM | 5.82 | Agonist activity at PPARalpha (unknown origin) | 31930920 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17524639 | 10.1016/j.bmcl.2007.05.007 | Peroxisome proliferator-activated receptor delta | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 17524639 | 10.1016/j.bmcl.2007.05.007 | Peroxisome proliferator-activated receptor gamma | 1 |
| 17524639 | 10.1016/j.bmcl.2007.05.007 | Peroxisome proliferator-activated receptor alpha | 1 |
| 31930920 | 10.1021/acs.jmedchem.9b01701 | Peroxisome proliferator-activated receptor alpha | 1 |
| 31930920 | 10.1021/acs.jmedchem.9b01701 | Peroxisome proliferator-activated receptor gamma | 1 |
| 31930920 | 10.1021/acs.jmedchem.9b01701 | Peroxisome proliferator-activated receptor delta | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
| 32339855 | 10.1016/j.ejmech.2020.112311 | Peroxisome proliferator-activated receptor delta | 1 |
Data from ChEMBL 36 via Core Engine