Assay Detail
Binding
CHEMBL4344276
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at FXR (unknown origin) by cell based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.06 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3822773 | PX-102 | 2.0 | 1 | 8.40 |
| CHEMBL4297613 | CILOFEXOR | 3.0 | 1 | 7.39 |
| CHEMBL566315 | OBETICHOLIC ACID | 4.0 | 1 | 7.07 |
| CHEMBL318457 | — | — | 1 | 7.05 |
| CHEMBL319544 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3822773 | PX-102 | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4297613 | CILOFEXOR | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL566315 | OBETICHOLIC ACID | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL318457 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL319544 | — | EC50 | = | 4100.0 | nM | 5.39 |