Assay Detail
Binding
CHEMBL4344283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ACC1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The Race to Bash NASH: Emerging Targets and Drug Development in a Complex Liver Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.55 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3407547 | FIRSOCOSTAT | 2.0 | 1 | 8.77 |
| CHEMBL4557289 | — | — | 1 | 8.52 |
| CHEMBL4567446 | CLESACOSTAT | 2.0 | 1 | 7.51 |
| CHEMBL4476176 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3407547 | FIRSOCOSTAT | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4557289 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4567446 | CLESACOSTAT | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4476176 | — | IC50 | = | 3900.0 | nM | 5.41 |