Assay Detail
ADMET
CHEMBL4344879
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Displacement of fluorescein labeled ATP probe from His/GST-tagged c-Met (unknown origin) incubated for 60 mins by HTRF assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.87 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4455682 | — | — | 1 | 8.60 |
| CHEMBL509101 | — | — | 1 | 8.24 |
| CHEMBL4476485 | — | — | 1 | 8.20 |
| CHEMBL4572309 | — | — | 1 | 7.75 |
| CHEMBL4476076 | — | — | 1 | 6.52 |
| CHEMBL4542026 | — | — | 1 | 6.30 |
| CHEMBL4551490 | — | — | 1 | 5.96 |
| CHEMBL4468222 | — | — | 1 | 5.35 |
| CHEMBL4438939 | — | — | 1 | 4.92 |
| CHEMBL4552106 | — | — | 1 | - |
| CHEMBL4434881 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4455682 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL509101 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4476485 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL4572309 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4476076 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4542026 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4551490 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4468222 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4438939 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4552106 | — | IC50 | - | — | - | |
| CHEMBL4434881 | — | IC50 | > | 1500.0 | nM | - |