Assay Detail
Binding
CHEMBL4344883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluorescein labeled ATP probe from full length His/GST-tagged RIPK3 (unknown origin) incubated for 60 mins by HTRF assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Receptor-interacting serine/threonine-protein kinase 3 (CHEMBL1795199) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.22 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4455682 | — | — | 1 | 8.54 |
| CHEMBL4476485 | — | — | 1 | 8.10 |
| CHEMBL4552106 | — | — | 1 | 7.80 |
| CHEMBL4438939 | — | — | 1 | 7.30 |
| CHEMBL4476076 | — | — | 1 | 7.06 |
| CHEMBL4551490 | — | — | 1 | 7.04 |
| CHEMBL509101 | — | — | 1 | 6.75 |
| CHEMBL4434881 | — | — | 1 | 6.75 |
| CHEMBL4542026 | — | — | 1 | 6.50 |
| CHEMBL4572309 | — | — | 1 | 6.40 |
| CHEMBL4468222 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4455682 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4476485 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4552106 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4438939 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4476076 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4551490 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL509101 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4434881 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4542026 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4572309 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4468222 | — | IC50 | > | 15000.0 | nM | - |