Assay Detail
Binding
CHEMBL4345130
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full-length N-terminal His6-tagged human IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR peptide as substrate after 90 mins by fluorescence polarisation assay
21
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Interleukin-1 receptor-associated kinase 4 (CHEMBL3778) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 21 | 7.96 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475494 | — | — | 1 | 8.85 |
| CHEMBL4556091 | — | — | 1 | 8.72 |
| CHEMBL4466981 | — | — | 1 | 8.72 |
| CHEMBL4472406 | — | — | 1 | 8.66 |
| CHEMBL4545898 | — | — | 1 | 8.59 |
| CHEMBL4568894 | — | — | 1 | 8.47 |
| CHEMBL4445098 | — | — | 1 | 8.46 |
| CHEMBL4452765 | — | — | 1 | 8.43 |
| CHEMBL4566431 | — | — | 1 | 8.43 |
| CHEMBL4473269 | — | — | 1 | 8.30 |
| CHEMBL4439292 | — | — | 2 | 8.21 |
| CHEMBL4536154 | — | — | 1 | 8.11 |
| CHEMBL4444608 | — | — | 1 | 7.85 |
| CHEMBL4537890 | — | — | 1 | 7.72 |
| CHEMBL4464216 | — | — | 2 | 7.66 |
| CHEMBL4468790 | — | — | 1 | 7.58 |
| CHEMBL4557715 | — | — | 1 | 7.52 |
| CHEMBL4592237 | — | — | 1 | 7.10 |
| CHEMBL4518564 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475494 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL4556091 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL4466981 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL4472406 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL4545898 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL4568894 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL4445098 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL4566431 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4452765 | — | Ki | = | 3.7 | nM | 8.43 |
| CHEMBL4473269 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4439292 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL4536154 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL4444608 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL4537890 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL4464216 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL4468790 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL4557715 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL4592237 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL4439292 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL4518564 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL4464216 | — | Ki | = | 490.0 | nM | 6.31 |