Assay Detail
Binding
CHEMBL4345288
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 6N-FAM from SF1 LBD (218 to 461 residues) (unknown origin) expressed in Escherichia coli BL21 pLysS by competitive binding based fluorescence polarization assay
9
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.56 | 6.38 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4467442 | — | — | 1 | 6.38 |
| CHEMBL4288877 | — | — | 1 | 6.07 |
| CHEMBL4551205 | — | — | 2 | 5.85 |
| CHEMBL1765959 | — | — | 1 | 5.48 |
| CHEMBL4452196 | — | — | 1 | 5.11 |
| CHEMBL4448429 | — | — | 1 | 4.46 |
| CHEMBL259067 | — | — | 1 | - |
| CHEMBL1325149 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4467442 | — | Ki | = | 418.0 | nM | 6.38 |
| CHEMBL4288877 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL4551205 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL1765959 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL4452196 | — | Ki | = | 7800.0 | nM | 5.11 |
| CHEMBL4448429 | — | Ki | = | 34670.0 | nM | 4.46 |
| CHEMBL4551205 | — | Inhibition | - | % | - | |
| CHEMBL259067 | — | Ki | - | — | - | |
| CHEMBL1325149 | — | Ki | - | — | - |