Assay Detail
Binding
CHEMBL4345303
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant His-tagged c-Kit cytoplasmic domain (544 to 976 residues) expressed in baculovirus expression system using Ser/Thr 6 peptide as substrate after 1 hr in presence of 300 uM ATP by FRET based Z'-LYTE assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and Optimization of 3'-(Imidazo[1,2-a]pyrazin-3-yl)-[1,1'-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.55 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464080 | — | — | 1 | 7.14 |
| CHEMBL4473475 | — | — | 1 | 6.21 |
| CHEMBL4519510 | — | — | 1 | 5.77 |
| CHEMBL4438475 | — | — | 1 | 5.54 |
| CHEMBL4583783 | — | — | 1 | 5.43 |
| CHEMBL4575992 | — | — | 1 | 5.40 |
| CHEMBL4544048 | — | — | 1 | 5.31 |
| CHEMBL4466438 | — | — | 1 | 5.30 |
| CHEMBL4586565 | — | — | 1 | 5.22 |
| CHEMBL4571430 | — | — | 1 | 5.18 |
| CHEMBL4444612 | — | — | 1 | 5.08 |
| CHEMBL4583808 | — | — | 1 | 5.05 |
| CHEMBL4559959 | — | — | 1 | - |
| CHEMBL4534464 | — | — | 1 | - |
| CHEMBL4470983 | — | — | 1 | - |
| CHEMBL2336015 | — | — | 1 | - |
| CHEMBL4535081 | — | — | 1 | - |
| CHEMBL4447486 | — | — | 1 | - |
| CHEMBL4590224 | — | — | 1 | - |
| CHEMBL4565522 | — | — | 1 | - |
| CHEMBL4555024 | — | — | 1 | - |
| CHEMBL4440007 | — | — | 1 | - |
| CHEMBL4547295 | — | — | 1 | - |
| CHEMBL4438214 | — | — | 1 | - |
| CHEMBL4519003 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464080 | — | IC50 | = | 72.4 | nM | 7.14 |
| CHEMBL4473475 | — | IC50 | = | 619.7 | nM | 6.21 |
| CHEMBL4519510 | — | IC50 | = | 1686.0 | nM | 5.77 |
| CHEMBL4438475 | — | IC50 | = | 2917.0 | nM | 5.54 |
| CHEMBL4583783 | — | IC50 | = | 3721.0 | nM | 5.43 |
| CHEMBL4575992 | — | IC50 | = | 3984.0 | nM | 5.40 |
| CHEMBL4544048 | — | IC50 | = | 4934.0 | nM | 5.31 |
| CHEMBL4466438 | — | IC50 | = | 4994.0 | nM | 5.30 |
| CHEMBL4586565 | — | IC50 | = | 5978.0 | nM | 5.22 |
| CHEMBL4571430 | — | IC50 | = | 6591.0 | nM | 5.18 |
| CHEMBL4444612 | — | IC50 | = | 8414.0 | nM | 5.08 |
| CHEMBL4583808 | — | IC50 | = | 8990.0 | nM | 5.05 |
| CHEMBL4559959 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4534464 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4470983 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2336015 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4535081 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4447486 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4590224 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4565522 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4555024 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4440007 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4547295 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4438214 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4519003 | — | IC50 | > | 10000.0 | nM | - |