Assay Detail
Functional
CHEMBL4345340
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Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay
16
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Functional-Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased Ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.72 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | — | 2 | 8.16 |
| CHEMBL4564103 | — | — | 2 | 5.41 |
| CHEMBL4579687 | — | — | 2 | 5.29 |
| CHEMBL4513262 | — | — | 2 | 5.13 |
| CHEMBL4439029 | — | — | 2 | 5.07 |
| CHEMBL4467483 | — | — | 2 | 4.83 |
| CHEMBL4442011 | — | — | 2 | - |
| CHEMBL4589737 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62 | SCH-23390 | IC50 | = | 6.918 | nM | 8.16 |
| CHEMBL62 | SCH-23390 | IC50 | = | 6.96 | nM | 8.16 |
| CHEMBL4564103 | — | IC50 | = | 3890.45 | nM | 5.41 |
| CHEMBL4564103 | — | IC50 | = | 3887.0 | nM | 5.41 |
| CHEMBL4579687 | — | IC50 | = | 5128.61 | nM | 5.29 |
| CHEMBL4579687 | — | IC50 | = | 5115.0 | nM | 5.29 |
| CHEMBL4513262 | — | IC50 | = | 7413.1 | nM | 5.13 |
| CHEMBL4513262 | — | IC50 | = | 7461.0 | nM | 5.13 |
| CHEMBL4439029 | — | IC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL4439029 | — | IC50 | = | 8590.0 | nM | 5.07 |
| CHEMBL4467483 | — | IC50 | = | 14791.08 | nM | 4.83 |
| CHEMBL4442011 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4589737 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4467483 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4442011 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4589737 | — | IC50 | > | 10000.0 | nM | - |