Assay Detail
Functional
CHEMBL4345833
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Antitrypanosomal activity against blood stream form of Trypanosoma brucei brucei S427 trypomastigotes overexpressing NTR assessed as inhibition of parasite growth
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.29 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4565434 | — | — | 1 | 7.70 |
| CHEMBL4559873 | — | — | 1 | 7.00 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 6.22 |
| CHEMBL4556532 | — | — | 1 | 6.05 |
| CHEMBL4170207 | — | — | 1 | 5.41 |
| CHEMBL4547155 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4565434 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4559873 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL290960 | NIFURTIMOX | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4556532 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4170207 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4547155 | — | EC50 | = | 4200.0 | nM | 5.38 |