Assay Detail
Functional
CHEMBL4345834
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Antitrypanosomal activity against bloodstream form of wild type Trypanosoma brucei brucei S427 trypomastigotes assessed as inhibition of parasite growth
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.47 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4565434 | — | — | 1 | 6.52 |
| CHEMBL290960 | NIFURTIMOX | 4.0 | 1 | 5.72 |
| CHEMBL4559873 | — | — | 1 | 5.40 |
| CHEMBL4547155 | — | — | 1 | 5.27 |
| CHEMBL4556532 | — | — | 1 | 5.17 |
| CHEMBL4170207 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4565434 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL290960 | NIFURTIMOX | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4559873 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4547155 | — | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL4556532 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4170207 | — | EC50 | = | 17700.0 | nM | 4.75 |