Assay Detail
Binding
CHEMBL4345979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to HIV1 NL4-3 capsid protein hexamer by SPR analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Structural capsid protein (CHEMBL2366504) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 5.67 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1229713 | — | — | 1 | 7.03 |
| CHEMBL4436876 | — | — | 1 | 5.92 |
| CHEMBL4559349 | — | — | 1 | 5.89 |
| CHEMBL4471665 | — | — | 1 | 5.58 |
| CHEMBL4573304 | — | — | 1 | 5.52 |
| CHEMBL4566312 | — | — | 1 | 5.35 |
| CHEMBL4571968 | — | — | 1 | 5.10 |
| CHEMBL4543615 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1229713 | — | Kd | = | 93.0 | nM | 7.03 |
| CHEMBL4436876 | — | Kd | = | 1190.0 | nM | 5.92 |
| CHEMBL4559349 | — | Kd | = | 1300.0 | nM | 5.89 |
| CHEMBL4471665 | — | Kd | = | 2630.0 | nM | 5.58 |
| CHEMBL4573304 | — | Kd | = | 3020.0 | nM | 5.52 |
| CHEMBL4566312 | — | Kd | = | 4450.0 | nM | 5.35 |
| CHEMBL4571968 | — | Kd | = | 7990.0 | nM | 5.10 |
| CHEMBL4543615 | — | Kd | = | 11800.0 | nM | 4.93 |